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Why does MOTS-c decline as we age?

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6.3 Metabolic diseases Aging imposes progressive physiological changes that compromise metabolic homeostasis and increase susceptibility to the development of conditions such as insulin resistance, visceral obesity, and type 2 diabetes (T2D) (Poggiogalle et al., 2018)

Ginsenoside Rg3 prevents CUSinduced reductions of 5HT levels in the prefrontal cortex and hippocampus, suggesting that its antidepressant-like effects are closely associated with the stabilization of serotonergic signaling [41]