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In another assay, 5 M MK-2206 2HCl (Akt inhibitor) was applied to DPCs for 1 h before treatment with WECP

A functional network was constructed using MetaboAnalyst 6.0 annotation terms of metabolites to provide a comprehensive visualization of the relationships among glucose-related (D-glucose, lactic acid, citric acid, and mevalonate), glutamate-related (glutamate, glutamine, glycine, aspartate, and DMG), and glutathione-related (pyroglutamate, adenosyl homocysteine, GSSG, and GSH) metabolites, as well as their predicted downstream metabolites (Fig

Subsequently, 3-phosphohydroxypyruvate accepts an amino group from ketoglutarate under the catalysis of phosphoserine aminotransferase 1 (PSAT1), yielding phosphoserine

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