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Not only is it central in the process of BBB disruption and the instigation of the inflammatory response, it also is directly affected by bioenergetic failure from hypoxia, which, among other processes, causes glutamate-induced excitotoxicity, where astrocytes play a pivotal role ( Discussion Despite decades of research on ME/CFS, there remains a fundamental haziness around its pathobiological matrix

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11.79

Leaf on human squamous cell carcinoma 15 cell line

B Bizarre (Idiosyncratic/Allergic): Unpredictable, not dose-dependent reactions such as allergies