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Xanthine oxidase, in the process of generating uric acid, generates oxidants such as O 2 . and H 2 O 2 [22]

Specifically, germ-free mouse models or FMT can be adopted to confirm a causal chain that iron overload mediates a reduction of gut Lactobacillus , which in turn aggravates the development of OA

It is widely studied in experimental models involving tissue regeneration, injury repair, and inflammatory response modulation

Consistent with their important roles in maintaining health, mutations in ATP7A and ATP7B cause inherited disorders of Cu metabolism, which have been recognized as Menkes disease (MD) and Wilsons disease (WD), respectively