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408 Studies have shown that the loss of GLP-1R in astrocytes can impair mitochondrial integrity, leading to the dysfunction and inhibition of glucose uptake and -oxidation

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showed that increased SLC2A5 (GLUT5) expression in pediatric Ph+ALL correlates with disease relapse and treatment resistance, and notably, tyrosine kinase inhibitors reduce GLUT5 expression, thereby decreasing fructose uptake (134)

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