Disclosures: Hong Yu: Nothing to Disclose, Yi Jiang: Nothing to Disclose 1251 HLA-B*35:01 ALLELE IS A RISK FACTOR FOR DRUG-INDUCED LIVER INJURY DUE TO ANTI-HYPERTENSIVES Lily Dara 1 Paola Nicoletti 2 Chaudry Majeed 3 Andrew Dellinger 4 David Kleiner 5 Mahmoud Mohamed 1 Tatyana Kushner 2 Mohammed Umair Masood 2 Raj Vuppulanch 6 Huiman Barnhart 7 Jiezhun Gu 7 Herbert Bonkovsky 3 , 1 University of Southern California, 2 Icahn School of Medicine at Mount Sinai, 3 Wake Forest University School of Medicine and Atrium Health Wake Forest Baptist, 4 Duke Molecular Physiology Institute, Duke University School of Medicine, 5 Department of Pathology, National Cancer Institute, Bethesda, 6 Indiana University School of Medicine, 7 Duke Clinical Research Institute Background: Anti- hypertensives (Anti-HTN) are used worldwide
Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, Bion J, Romand JA, Villar J, Thorsteinsson A, et al
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This may be in response to IOP-induced stress on glia, rather than purely a response to retinal ganglion cell metabolic dysfunction