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These findings indicate that iron has a greater inhibitory effect on osteoblast precursors than on mature osteoblasts during osteogenic induction, which is similar to the regulation of osteoclasts by TFR1

Tommy et al., 2021), (b) some of their pharmacogenomics target genes (e.g., Sm11/leucovorin downregulates IFNG, the gene coding for the inflammatory cytokine Interferon gamma ) , and (c) their abovementioned anti-correlative genes hubs are mainly related to immune and inflammation processes

S -nitrosocysteine and glutathione depletion synergize to induce cell death in human tumor cells: insights into the redox and cytotoxic mechanisms

found that constitutive IFN- signaling induced by depletion of the tumor suppressor transcription factor Elf5, together with its ubiquitin ligase FBXW7, increases the number of highly immunosuppressive neutrophils in the TME, which in turn promotes tumor growth and metastasis, leading to a worse prognosis of TNBC (144)