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410: Prevention, Screening, Diagnosis, and Pregnancy Management for Fetal Neural Tube Defects

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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

The results showed that vitamin B complex treatment reduced proinflammatory cytokine expression while increasing anti-inflammatory cytokine expression, and this led to neuroinflammation resolution