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SCUJ 5(1):2330

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The consumption of glutathione (GSH) can lead to the inactivation of GPX4 (58)

5a) was reported by Pillow and colleagues, who conjugated the BRD4-targeting PROTAC GNE-987 to a C-type lectin domain family 12 member A (CLL1) antibody via a methanethiosulfonate (MTS) group, demonstrating that this strategy markedly improves the pharmacokinetic profile and degradation efficiency of the PROTAC [216]