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Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming

Side effects with NAC supplements include gastrointestinal symptoms, which occur in up to 23% of patients.[ref] While generally safe at supplemental doses, a drawback to N-acetyl cysteine is the sulfur smell and taste

Pyruvate (10 mM), glutamate (20 mM) and succinate (10 mM) and glycerol-phosphate were added to evaluate ADP-stimulated respiration when NADH and succinate-linked pathways are simultaneously transferring electrons to the Q junction (Oxphos complexes I + II)