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In murine colitis, melatonin reduces the generation of ROS and reactive nitrogen species (RNS), characterized by lowering colonic MDA levels and MPO activity and improved antioxidant defenses with increased GSH and SOD levels in the colon (134)

In both cases, sulforaphane exerts a neuroprotective role, suppressing inflammatory signaling and ROS generation (Bobermin et al., 2020

This, in turn, promotes the accelerated damage of the mitochondria, leading to apoptosis and finally resulting in the process of aging (Iakovou and Kourti, 2022)

This research is valuable for further exploration and identification of heat-resistant genes in seagrass