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p is 0 or 1 L 1 is a bifunctional linker, such as, for example, NH(CH 2 CH 2 O) n (CH 2 ) n NR 3 , NH(CH 2 CH 2 O) n C(O), NH(CR 4 R 5 ) n OC(O), C(O)(CR 4 R 5 ) n NHC(O)(CR 8 R 7 ) q NR 3 , C(O)O(CH 2 ) n O C(O)(CR 4 R 5 ) n NR 3 , C(O)NH(CH 2 CH 2 O) n (CH 2 ) n NR 3 , C(O)O(CH 2 CH 2 O) n NR 3 , C(O)NH(CR 4 R 5 ) n O, C(O)O(CR 4 R 5 ) n O, C(O)NH(CH 2 CH 2 O) n , R 2 , R 3 , R 4 , R 5 , R 7 and R 8 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy

However, this heightened production may be associated with diminished functionality and efficiency, likely due to alterations in NET composition and impaired clearance mechanisms [166]

The dosage of the medications was based on previous studies involving rats

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