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Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

Preclinical and clinical studies have demonstrated its efficacy in reducing body weight both as a monotherapy and in combination with GLP-1 receptor agonists such as semaglutide, highlighting its potential as a next-generation therapeutic agent for obesity and metabolic syndrome management

Not exactly inspiring physician confidence

Cardiometabolic secondary endpoints, including measures such as waist circumference and blood pressure, were reported directionally in favor of the combination arm