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DISC consists of FADD, pro-caspase-8 and the cellular FLICE inhibitory proteins (c-FLIPs)

Its defining trait in the research literature is selectivity: unlike older GHRPs such as GHRP-6 or GHRP-2, ipamorelin is reported to release GH without meaningfully raising cortisol, prolactin, ACTH, or aldosterone, and with only minimal appetite stimulation