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Here's the honest answer: most researchers who report 'non-response' to 5-Amino-1MQ never had a peptide problem

(PubMed) Disclaimer The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public

If we answer the question of who such approaches are considered for, first and foremost these are patients for whom it is important to slow progression rather than simply eliminate symptoms