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Arafa MA, Ismail HM, Farhat KH, Aly S, Rabah DM, Althynayan AM et al

Large hydrophilic chelators, such as DFO (a highly polar molecule with a molecular weight of 560 Da), exhibit poor BBB permeability when administered intravenously, remaining in the circulation and extracellular space, while only minimal amounts can cross into the brain parenchyma