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Artesunate inhibited the Notch signaling pathway, decreased Jagged1, NICD, and Hes-1 protein expression, reduced TGF-induced -smooth muscle actin (-SMA) and collagen content in fibroblasts, and inhibited the differentiation of fibroblasts into myofibroblasts (Liu et al., 2017)

Tesamorelin can also be combined with local repair peptides (BPC-157, TB500)

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The complexity and diversity of HCC can be attributed to the distinct genetic and molecular profiles present in the disease, ranging from early to advanced stages