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These conditions create chronic inflammatory states that further deplete B12 levels while increasing metabolic demand for this essential nutrient

doi: 10.1016/j.cclet.2023.108230 173 WangJ.LiY.HuangZ.WanW.ZhangY.WangC.et al

A critical assessment of the factors affecting reporter gene assays for promoter SNP function: a reassessment of -308 TNF polymorphism function using a novel integrated reporter system