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The ethanol-inducible form of P450 2E1 has been recognized as one of the prevailing mechanisms responsible for the generation of superoxide anion from ethanol and subsequent ethanol-induced lipid peroxidation.30,31 with a major involvement of GSH depletion.32 P450 2E1 has a very efficient NADPH oxidase activity which generates substantial amount of superoxide anion and H2O2 as well as hydroxyethyl radicals, all likely to be responsible for ethanol induction of oxidative stress and lipid peroxidation

Furthermore, while the N-terminal self-cleaving reaction was very inefficient for these split inteins, the C-terminal cleaving reaction occurred even when the five native flanking C-extein amino acids were absent

Influence of genetic background on apathy-like behavior in triple transgenic AD mice

In simpler terms, it's like sending out a VIP invite (the antibody) to your favorite proteinand seeing which other proteins tag along to the party