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Direct Metabolic Effects Lipolysis and Insulin Antagonism Beyond IGF-1-mediated anabolic effects, HGH 191AA exerts direct metabolic actions via GHR signalling: stimulating lipolysis in adipose tissue (increasing free fatty acid mobilisation), promoting nitrogen retention and protein synthesis in muscle, and antagonising insulin signalling producing a relative insulin resistance in peripheral tissues that directs metabolic substrate use towards fat oxidation and spares carbohydrate for glucose-dependent tissues