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Especially preferred are polynucleotide variants containing alterations which produce silent substitutions, additions, or deletions, but do not alter the properties or activities of the encoded polypeptide

However, adaptive immunity is much more complex than innate immunity because it involves antigen-specific responses and immunologic "memory." Exposure to a specific antigen on an invading pathogen stimulates production of immune cells that target the pathogen for destruction (1)

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