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At the same time, those affected with Crohns often undergo surgeries that involve the removal of at least a portion of the terminal ileum, placing them at further risk for a vitamin B12 deficiency

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[153] has elucidated that the downregulation of hepatic ACSL4 in hepatocytes within a murine model fed a hyperlipidemic diet results in a diminished accumulation of lipids and an exacerbation of insulin resistance

This damage not only contributes to the diseases initiation but also activates inflammatory signaling pathways, further amplifying the inflammatory cascade