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So, Im thinking, well, when you forget stuff, a name or something, Oh man, that must be my amyloid and tau in my brain, whatever. So, this breakthrough, the biggest breakthrough in neuroscience in decades, is this p-tau217

Under conditions of hepatic copper excess, the high-affinity transporter CTR1 undergoes endocytosis and degradation to reduce further uptake, while ATP7B expression is upregulated to promote copper excretion via bile (29,51)

At higher maintenance doses like 2.4mg per week, a 10mg vial lasts roughly four weeks, which aligns neatly with the 28-day stability window

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease