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Melatonin and melatonin receptor agonists have therapeutic uses in a range of circadian-related conditions, such as jet lag, shift work sleep disorders, delayed sleep phase syndrome, seasonal affective disorder and non-24 h sleepwake disorder, and major depression (de Bodinat et al

doi: 10.1016/j.cell.2013.12.010 182 ZhuSZhangQSunXZehHJ3rdLotzeMTKangRet al

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1;149(1):42433 Poncin S, Colin IM, Grard AC (2009) Minimal oxidative load: a prerequisite for thyroid cell function