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In: Greenspan's Basic & Clinical Endocrinology

Paradoxically, this event does not decrease mGSH in cancer cells because of the adaptive overexpression of 2-oxoglutarate transporter (2-OGC or SLC25A11) through hypoxia-inducible factor-1 (HIF-1) stabilization [125, 126, 152]

Bidirectional regulation of NF-B by reactive oxygen species: a role of unfolded protein response

From the view of the cytokine profile of IgG4-RD includes Th2 cytokines (IL-4, IL-5, and IL-13) and regulatory cytokines (IL-10 and tumor growth actor [TGF]-), the Th2 immune response play a key role in the pathophysiology of type1 AIP including IgG4-RD [76,77,78,79]