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This differs fundamentally from conventional sleep aids that work acutely and wear off

Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone

[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Nilsen M.S., Jersin R.A., Ulvik A., Madsen A., McCann A., Svensson P.A., Svensson M.K., Nedrebo B.G., Gudbrandsen O.A., Tell G.S., et al