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Providers who work with patients on hormone optimization therapy often find that anxiety management is a necessary component of any broader hormonal protocol

Documentation must include the date and provider credentials, the specific counseling topic(s) addressed, the total face-to-face counseling time (minimum 8 minutes), the patients response and any agreed behavioral goals, and a supporting ICD-10-CM Z-code diagnosis

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This trial, while not showing superiority of JTA-004 over placebo in the overall population, provides highly valuable insights into clinical trial design, placebo responses, and the potential need for better patient stratification in osteoarthritis research