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Likewise, less COX2 may reflect its particular anti-inflammatory effects, like that noted in the counteraction of the cachexia induced by tumors in mice [4], muscle wasting, deranged muscle proliferation and myogenesis, an increase of the proinflammatory cytokines (i.e., IL-6, TNF-) and the changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3

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(127) have shown that circulating IGF-I levels are related to the histological stages of MASLD