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Another glutaminase inhibitor, JHU-083, extensively inhibits Gln-metabolizing enzymes and increases the concentrations of Gln and glucose in the TME by inhibiting glycolysis, relieving the hypoxic state

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The mild enhancement in the arterial phase can be homogenous or diffusely heterogeneous, while in the parenchymal phase, it may be homogenous or with a dotted pattern

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