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These include prodrug strategies, nanotechnology-based delivery systems, conjugation with different polymers (e.g., PEG), encapsulation with the use of metalorganic frameworks, targeted delivery using ligand conjugation (e.g., peptides and antibodies), or manufacture of inhalable devices (e.g., intranasal administration)

Consistent with the diabetic phenotype, changes in metabolic processes were observed, including downregulation of branched-chain amino acid metabolism and glutamate metabolism, while some proteins in pathways related to fatty acid metabolism were upregulated and others downregulated

intravenously injected frozen-thawed or fresh mitochondria into mice resuscitated from cardiac arrest, it was found that injection of fresh mitochondria elevated ATP content and increased survival from 55% to 91% at 72 h after resuscitation from cardiac arrest

and Lee et al