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256 For example, the myristoylation of virus-encoded protein (VP0) in rhinoviruses and the gag or nef protein in HIV-1 is vital for viral replication, assembly, and infection 257,258,259 The high cell membrane affinity or changed protein activity caused by the myristoyl moiety contributes a lot to these biological processes

43 This suggests that this mtDNA mutation is a risk factor that requires interactions with nuclear mutations, polymorphisms or epigenetics and/or environmental triggers or modulators in order for the disease phenotype to be expressed

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