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(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies

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As a result, older people are more likely to have physical hollows beneath their eyes that cast a shadow

To help prevent deficiency, a person can eat foods high in vitamin B12 or take a supplement.