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Although the characteristic symptoms are descriptive for each neurodegenerative disease, it appears that elevation of the oxidative state of the cells at specific regions in the brain is an important factor in the etiology of Parkinson's disease, basal ganglia degenerative diseases, motoneuron diseases, Alzheimer's and also the Creutzfeldt-Jakob's disease

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Frequent temperature fluctuations-such as repeatedly moving them in and out of the fridge-can destabilize the vitamin, potentially reducing its effectiveness