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Asct2 overexpression is associated with poor survival of oscc patients and Asct2 knockdown inhibited growth of glutamine-addicted oscc cells

These include inhibition of tumor growth and proliferation, induction of apoptosis in cancer cells, downregulation of the nuclear factor kappa b (NF-B) pathway, cytokine regulation, upregulation of MAP kinase phosphatase 5 (MKP5), and inhibition of cyclooxygenase 2 (COX-2) (224227)

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The C5aC5aR interaction on trophoblast cells polarizes them toward an anti-angiogenic phenotype by balancing their angiogenic factors, such as sFlt1 or soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and PIGF (410, 413)