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10.1089/jop.2000.16.121 J Ocul Pharmacol Ther

miRNAs typically function by interacting with mRNAs of target genes and hindering the successful translation of their proteins, and miRNA regulation can occur in various biological processes during tumour development, such as growth, angiogenesis, and metastasis (Lee and Dutta, 2009)

97 Other promising investigational CRISPR-Cas9 based gene-editing medicines are currently being evaluated in Phase 3 pivotal studies for transthyretin amyloidosis associated cardiomyopathy and neuropathy (NTLA-2001) and hereditary angioedema (NTLA-2002)

In conclusion, our data reveal that targeting estrogen-regulated SLC7A11 and SLC3A2 enhances ferroptosis in ER+ breast cancer, offering a novel therapeutic option for patients with ER+ breast cancer, particularly those with endocrine resistance