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Sensors 15 , 2888928914 (2015)

Experimental design After 20 days of growth, tissue culture plantlets were divided into five groups for experimental treatment: (1) T0 (untreated), (2) Cd48 (48 h of growth following the addition of 500 mol/L of CdCl 2 to MS solution), (3) GSH48 (48 h of growth following the addition of 500 mol/L of CdCl 2 and 400 mol/L of GSH to MS solution), (4) Cd96 (96 h of growth following the addition of 500 mol/L of CdCl 2 to MS solution), and (5) GSH96 (96 h of growth following the addition of 500 mol/L of CdCl 2 and 400 mol/L of GSH to MS solution)

and iii) shaping the tumor microenvironment for malignant cells to escape immune surveillance

However, it has been reported that oxaliplatin enhances the oxidative stress in also the central nerve system, such as brain and spinal cord 38,39,40,41,42,43