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2008 Jan Charles G Helmick, David T Felson, Reva C Lawrence, Sherine Gabriel, Rosemarie Hirsch, C Kent Kwoh, Matthew H Liang, Hilal Maradit Kremers, Maureen D Mayes, Peter A Merkel, Stanley R Pillemer, John D Reveille, John H Stone, National Arthritis Data Workgroup

This destruction complex includes the following proteins: Axin, adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1 (CK1)

This approach helps preserve comparability across runs and allows later replications to be performed under comparable assumptions

Clinical trials have validated sorafenibs efficacy in prolonging the overall survival (OS) of advanced HCC patients (Llovet et al., 2008)