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The researchers did not observe an effect on high-density lipoprotein cholesterol

An important methodological difference between the two studies is that Bartnik-Olson and colleagues had a healthy, non-injured comparison group whereas our study had an OI comparison group

In this work, by estimating the Gibbs free energy change ( G ) of the break/reform of Cu 2+ /histidine coordination with different manner, a Cu catalytic site with optimized coordination environment of one amino, one carboxyl and two imidazolyls is proposed