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Compared with the no treatment diabetic animal model group, CF extract (at 300 mg kg 1 2 day 1 and 400 mg kg 1 day 1 p.o.), loganin, morroniside, and ursolic acid (each at 200 mg kg 1 day 1 p.o.) for 4 weeks can significantly decrease fasting blood glucose and alleviate polyphagia, polydipsia, polyuria, and weight loss [13, 14]