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Another Parkinsonian model employing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity found that UA could reduce oxidative stress, inflammation, and dopaminergic neuronal dysfunction in the brain 35

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Moreover, -catenin recruits the transcription factor TCF4 to enhance SHMT2 expression, forming a positive feedback loop that sustains oncogenic signaling and promotes colorectal cancer cell proliferation and metastasis [139]