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Basic Clin Pharmacol Toxicol 100:308315 Fisher AEO, Naughton DP (2003) Redox-active metal ions and oxidative stress: therapeutic implications

Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides

Prior to docking, the receptor protein was further processed in PyMOL 2.5.2 to remove residual water molecules, salt ions, and small molecules