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These findings illustrate that OGT regulates de novo nucleotide synthesis by controlling the conversion of R5P to PRPP

Repouskou, A

doi: 10.1016/j.cell.2023.02.021 53 AlonsoRFlamentHLemoineSSedlikCBottassoEPguilletIet al

During niacin treatment, fasting glucose, insulin and HOMA1-IR (insulin resistance score based on blood glucose and insulin) increased in some individuals up to 1.9-fold after niacin dose of 500 mg, suggesting increased insulin resistance (Fig