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Some studies have found that intermittent hypoxia leads to the following changes: a decrease in total antioxidant capacity, an increase in MDA serum levels, a decrease in the activity of antioxidants (SOD, GSH-Px and GSR) of the testis and epididymis and a significantly reduced number of epididymal sperm [23, 24]

Microorganisms, including Escherichia coli or Clostridium species, produce enzymes like beta-glucuronidase, which hydrolyse conjugated bilirubin back into its unconjugated form, increasing the probability of precipitation [27, 35]

A recent epidemiological study revealed that the worldwide prevalence of FC and IBS-C in adults is 11.7% and 1.3% respectively [2]

18th World Congress of the World Society of Cardio-Thoracic Surgeons, 2008