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3.2.3 Myocarditis Myocarditis is an inflammatory heart disease that may be triggered by infections, exposure to toxic substances, and activation of the immune system

For example, ROS can reduce the expression and enzymatic activity of the DNA mismatch repair genes mutS homologue 2 and 6 and can increase the expression of DNA methyltransferases, leading to a global hypermethylation of the genome [60]

Furthermore, ROS stimulates endothelial cell dysfunction by scavenging NO directly or by oxidative modification of tetrahydrobiopterin resulting in eNOS uncoupling [110]

separate application or use stabilised derivatives recommended Retinoids work synergistically but may increase initial irritancy