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SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies

The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2

By inhibiting the NNMT enzyme, it prevents the consumption of nicotinamide, allowing it to be recycled back into NAD+ more efficiently