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To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

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The next-generation of antioxidant interventions will focus on spatial and temporal precision, like the NOX isoform-specific nanotherapy based on lipid nanoparticles encapsulating NOX1 siRNA ( Chronotherapeutic Nrf2 activation is being studied as an alternative for HTN treatment (Serrano and Medina, 2025)