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Furthermore, several terms upregulated in old indicate active metabolic detoxification processes (for example, alcohol metabolic process and cellular aldehyde metabolic process), as well as oxidative stress defense (for example, glutathione metabolic process) and remodeling of the extracellular matrix (for example, uronic acid metabolic process, extracellular matrix organization and biological adhesion)

4-HNE immunohistochemistry and image analysis for detection of lipid peroxidation in human liver samples using Vitamin E treatment in NAFLD as a proof of concept

10.1093/cvr/cvq325 177

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