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Their findings confirmed that CGRP and SP not only facilitate inflammatory cell infiltration via enhanced vasodilation and vascular permeability but also promote mast cell degranulation, leading to the release of histamine and proinflammatory mediators that aggravate erythema, edema, and itch [83]

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Health problems arise when there are imbalances, such as too many bound hormones (poor hormone signaling) or too many free hormones (excess hormones)