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Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreichs Ataxia

The most common causes include smoking, exposure to harmful dust, environmental factors, and certain medications

In one DAXI study, 95.7% of participants were somewhat satisfied, satisfied, or very satisfied with their results after four weeks, with the highest number of participants describing themselves as very satisfied

Experiments performed in differentiated SH-SY5Y neuroblastoma cells have shown that exposure to PS-NPs downregulates expression of the CI subunit NDUFB8, leading to diminished basal and maximal oxygen consumption rates alongside increased proton leakagefurther confirming mitochondrial CI dysfunction 32