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Abstract Impaired redox metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration and aging

Thus, these data indicate that EGF/ERK2 signaling substantially determines the integrity of the GSK3SIRT7 axis

Studies have demonstrated that serum 1,25(OH)D levels increase in CKD patients following kidney transplantation, indicating that the restoration of functional nephron mass can reestablish vitamin D activation capacity (Figure 2)

In one of these studies, the patient was female [76] and the authors were able to generate an isogenic control line in parallel to the diseased iPSC line, since X chromosomes are known to undergo random X-inactivation and, hence, monoclonal iPSC lines can be derived from somatic cells with an active healthy or diseased X-chromosome